As an example, they considered the enzymatic reaction of breaking a dimer into two monomer molecules. Considering the geometry of such an enzyme-substrate-complex, they identified three golden ...

As an example, they considered the enzymatic reaction of breaking a dimer into two monomer molecules. Considering the geometry of such an enzyme-substrate-complex, they identified three golden ...

The precise origin(s) of the catalytic power of enzymes remain(s ... to the chemical (reaction) coordinate — that is, the making and breaking of bonds — and whether this enhances the rate ...

By using a two-step computational design approach, in the present study, we have successfully engineered a cocaine-detoxifying enzyme ... the detailed reaction coordinate and free energy change ...