Enzymes can be involved at every step in a reaction pathway. At each step, the molecule is transformed into another form, due to the presence of a specific enzyme. Such a reaciton pathway can ...

The cell can control a metabolic pathway by the presence or absence of a particular enzyme. The cell can also regulate the rate of reaction of key enzymes. The binding of the enzyme to its ...

They show the parasites that cause leishmaniasis are vulnerable via a different pathway for biosynthesis of their ergosterol, known as the CYP5122A1 enzyme. Therefore, azole antifungals targeting ...

Northwestern Medicine investigators have discovered a novel mechanism that recognizes and eliminates "bad" transcriptional ...

The biosynthesis of cysteine occurs through a two-step enzymatic pathway involving serine acetyltransferase (CysE) and O-acetylserine sulfhydrylase (CysK/CysM). Recent research has focused on ...

A single cellular pathway helps drive almost one in four ... A lethal, mutant version of the KRAS signaling enzyme was often called undruggable—until researchers found a molecule that has ...

Their focus was on the enzyme IspD, which is responsible for the third step in the MEP Pathway. The researchers were able to solve the crystal structure of IspD from P. aeruginosa for the first ...

"The glycolytic enzyme aldolase is essential for liver cancer cells, although the glycolytic pathway itself is apparently dispensable," says metabolism expert Schulze, summarizing the findings.

Because cGAS was the only candidate that produced cGAMP activity, this finding solidified its place as the elusive cytosolic DNA sensor to complete the cGAS-cGAMP-STING pathway. “It was quite a ...