In most anaerobes, the same reaction is usually catalyzed by a single enzyme, pyruvate ... The thiamin pyrophosphate (TPP) cofactor and the three [4Fe–4S] clusters are suitably arranged to ...

These are known as cofactors, and without these enzymes remain within the inactive “apoenzyme” forms. Once the cofactor is added, the enzyme becomes the active “holoenzyme”.

It donates a methyl group to the enzyme’s cobalamin cofactor and then serves as a base when tryptophan removes that methyl group. That second part of the reaction is surprising, Booker says ...

Researchers have uncovered the structure of an enzyme that is crucial for maintaining ... and the β subunit houses the radical cofactor. Here, we present a 3.3-Å resolution structure by cryo ...

Previously, it had been believed that all the "players" -- the enzyme, cofactor, and substrate -- came together at a particular time to perform the function of transferring an oxygen atom from the ...

One enzyme that requires such assembly is the HYDA1 enzyme, which contains a complex cofactor, which is the area inside the enzyme where the actual hydrogen production takes place. The cofactor ...

The German team's 1.8-Å structure shows that the enzyme flips the CPD lesion into an active-site cavity right next to the catalytic flavin cofactor. This proximity suggests that the activated ...

but also the structure they need to make a better key -- a better drug inhibitor. "This is the first example of an enzyme that exploits the chirality of its cofactor in order to evade its ...

There, a third enzyme converts PTP into a well-known enzyme cofactor, called tetrahydrobiopterin (BH4). BH4 is required in the neurons that produce NPF, a neuropeptide that regulates feeding.

The researchers used site-specific mutagenesis to gain new insights into how the cofactor precursor is integrated into the ...

In this new effort, the researchers have found an exception—an algal photoenzyme that converts fatty acids to hydrocarbons using blue light and a riboflavin cofactor. The hydrocarbons produced ...