Docking works by allowing researchers to first determine the atom-by-atom structure of an enzyme and then screen many thousands of molecules for one that fits into the empty “active site” of the ...

A team of researchers, led by Professor Chae Un Kim from the Department of Physics at UNIST, has successfully tracked the ...

Knowing its 3-D structure will aid ... far occur within the cavity of the enzyme's active site, this does not mean they would not have an impact on its chemical function, since pretty much every ...

Computer algorithms have designed highly efficient synthetic enzymes from scratch, with minimal need for tedious hands-on ...

Published in the Journal of the American Chemical Society, the article presented detailed structural data on the enzyme's active state – the ... were able to provide evidence for a model of the active ...

at the active site of the AlkB enzyme (colorful ribbon structure). The magenta structure below the active site is the substrate (see close-up views).

Enzymes help with specific functions that are vital to the operation and overall health of the body. They help speed up chemical reactions ... an enzyme’s active site is a specific shape ...

report securing the structure of the active site core of topoisomerase II alpha in complex with DNA. They describe the conformational changes undergone by the enzyme during DNA binding and cleavage.

The enzyme, known as HIV-1 protease ... "Darunavir's structure allows it to create more hydrogen bonds with the protease active site than most drugs of its type, while the backbone of HIV-1 ...