From the endosome, receptors can take one of three routes: they can travel to the lysosome ... for signaling receptors to be sorted into the appropriate, slower recycling pathway rather than ...

From the endosome, receptors can take one of three routes: they can travel to the lysosome ... for signaling receptors to be sorted into the appropriate, slower recycling pathway rather than ...

They were able to identify a previously unknown signaling pathway in human cells that is driven by the protein SPG20. It recognizes damage to the outer side of the lysosomal membrane, binds to the ...

We find Coronin-1 to be necessary for NGF-dependent calcium release, which, through activation of calcineurin, allows the NGF-TrkA signaling endosome to evade lysosomal fusion and degradation at ...

Endocytosis and degradation of the membrane receptors in the lysosome controls the activation of intracellular signaling pathways, but the mechanisms ... US show that hepatocyte growth factor ...

They were able to identify a previously unknown signaling pathway in human cells that is driven by the protein SPG20. It recognizes damage to the outer side of the lysosomal membrane, binds to the ...

Damaged lysosomes are repaired by a lipid-based signaling pathway dubbed PITT that could be targeted to treat neurodegenerative disease, its discoverers say. Holly Barker is a freelance journalist ...

For the first time, the pathway through which cells repair damaged lysosomes ... The ORPs (oxysterol-binding protein (OSBP)-related protein) connect the PtdIns4P signaling molecule on the lysosome to ...

This project is to determine TFEB PTM signatures induced by tau that drive TFEB nuclear signaling. The hypothesis is that intraneuronal Tau accumulation acts as a lysosomal stress signal to activate ...

As such, therapeutic intervention targeting members of the ERK signaling pathway is a major endeavor among cancer researchers. “[The endosomal] pool of ERK activity depends on active ...

A protein called STING, previously shown to control a pathway that contributes to antiviral signaling ... that resulted in the production of more lysosomes. "Lysosomes are organelles that are ...