Insulin activates TRPM6 activity in the distal convoluted tubule. 34,62 Consequently, insulin resistance results in decreased renal magnesium reabsorption and increased magnesuria. Autoantibodies ...

Vasopressin also regulates salt transport in the distal convoluted tubule, which is present in each nephron a short distance downstream from the macula densa. It transports salt at a high rate but ...

Hypertension affects 1 billion people world-wide, contributing to 5 million deaths annually from myocardial infarction, stroke, kidney failure and heart failure. Its causes have been obscure owing ...

His team found that while AP-2β function in the kidney is required for survival by regulating the development and function of distal convoluted tubules, AP-2α is important for the proper ...

Genetic testing revealed heterozygous, biallelic, pathogenic variants in SLCl2A3, the gene that encodes the sodium chloride cotransporter in the distal convoluted tubule, confirming the diagnosis of ...

The third and final section is called the distal convoluted tubule (DCT) and is also located in the renal cortex. The DCT, as the name suggests, is the most distant and final part of the nephron ...

Draw a nephron, starting with the afferent arteriole, and then add Bowman’s capsule; proximal convoluted tubule; loop of Henlé; distal convoluted tubule and the collecting duct. Once the sections of ...

ADH acts on the kidneys to increase water permeability in the collecting duct and distal convoluted tubule. Specifically, ADH acts on transmembrane protein channels called aquaporins that open up ...