This base-to-base bonding is not random ... Beyond the ladder-like structure described above, another key characteristic of double-stranded DNA is its unique three-dimensional shape.

Phosphodiester bonds are crucial components of nucleic acids, linking nucleotides together in DNA and RNA. Understanding the mechanisms by which these bonds are cleaved is essential for various ...

The DNA repair and replication pathways converge on a common final step in which the continuity of the repaired DNA strand is restored by DNA ligase, an enzyme that converts nicks into phosphodiester ...

In a first-of-its-kind breakthrough, a team of UBC Okanagan researchers has developed an artificial adhesion system that closely mimics natural biological interactions. Dr. Isaac Li and his team ...

Nucleic acids are complex biological molecules that store and transmit genetic information in all living organisms. They are essential for the survival and reproduction of life on Earth. The two main ...

Overview of RNA repair – There is an emerging appreciation of the existence of “RNA repair” pathways that rely on RNA ligases to maintain or manipulate RNA structure in response ... seal the two ends ...

My scientific interests center on nucleases, a functionally diverse class of enzymes that catalyze the cleavage of phosphodiester bonds to support a wide breadth of pathways, including DNA replication ...