The enzymatic hydrolysis of DNA phosphodiester bonds has been widely studied, but the chemical reaction has not yet been observed. Here we follow the generation of a DNA double-strand break (DSB ...

Hydrogen bonds The hydrogen bonds between the base pairs form the double helical structure of DNA. There is no exchange or sharing of electrons in hydrogen bonds as seen in covalent or ionic bonds.

Like RNA and DNA, cyclic dinucleotides are composed of nucleotide building blocks joined by phosphodiester bonds.

DNA is made up of adenine-thymine (AT) bonds and guanine-cytosine (GC) bonds. The frequency of each type of bond differs substantially across bacterial species. A new study uses this quirk of ...

Their first attempt yielded a DNA that performed phosphodiester cleavage instead. “There’s something about an amide bond that is difficult to cleave—at least by a nucleic acid catalyst ...

RNA repair pathways rely on RNA ligases to maintain or manipulate RNA structure in response to biologically purposeful RNA cleavage events. The goal of this project is to illuminate the mechanisms and ...

The nucleotides are connected through phosphodiester bonds, forming a long chain. In DNA, two complementary strands of nucleotides pair up through hydrogen bonds between the bases (A with T and G with ...

RNA is a single stranded molecule containing a ribose sugar. It has a distinctive structure and, unlike DNA, there are variations and various types of RNA structures.

James Watson and Francis Crick revealed the structure of DNA — the genetic instructions in all living things — 70 years ago in the journal Nature. Watson and Crick could not have succeeded ...