A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed ...

Furthermore, new exons can be inserted into old introns, creating new proteins without disrupting the function of the old gene. Our knowledge of RNA splicing is quite new. Nonetheless, because ...

Johns Hopkins researchers have developed a powerful new AI tool called "Splam" that can identify where splicing occurs in genes—an advance that could help scientists analyze genetic data with ...

Alternative splicing plays a pivotal role in defining cell phenotypes and physiology in multicellular eukaryotes, often distinguishing between cell types more accurately than gene expression. 1 During ...

For instance, they can compare characteristic sequences of the gene and corresponding pre-mRNA, as well as splicing factors, across multiple experiments. These metacomparisons will integrate large ...

The splicing reaction would happen inside the speckle ... Guttman and his team are interested in how nuclear organization influences different quantitative aspects of gene regulation. Toward this end, ...

Alternative splicing is crucial for eukaryotic gene expression and influences protein function and regulation, with mis-splicing linked to numerous diseases. In this webinar, Dr. Megan L Noonan will ...