Now, researchers have built the first model system to decipher what goes on at the 'replication fork' -- the point where DNA is split down the middle in order to create two exact copies.

Given its importance, DNA replication is tightly regulated, primarily upon initiation at genomic sites known as origins of replication. A two-pronged structure known as a replication fork forms at ...

Furthermore, some features of DNA replication observed in mouse ES cells are shared with human iPS cells, suggesting that the slow replication fork with high origin density may be a hallmark of ...

In contrast, 8-cell embryos are much more similar to mature cells, showing sequential replication and fast fork movement. Errors in DNA replication in the first few days after fertilization often ...

the progression of DNA replication forks also slows down. Replication forks, so-called because their structure resembles a fork, are where large groups of proteins coordinate genome replication ...

Accurate transmission of the genetic information requires complete duplication of the chromosomal DNA each cell division cycle. However, the idea that replication forks would form at origins of DNA ...

So, as you can imagine, if a cell is trying to replicate its DNA, and the replication fork is going along and encounters an area with unrepaired DNA damage, the replication fork can't progress ...

In the circular Escherichia coli chromosome, replicating DNA splits into two forks heading in opposite directions. Convergence of the forks is regulated by directional barriers that consist of Tus ...

leading to an arrest of the DNA replication fork, the actual site of DNA synthesis. Arrested replication forks are prone to collapse, posing serious threats to genomic integrity, suggesting that DNA ...

Researchers at Helmholtz Munich have now made a new discovery, which is described in a paper (“DNA replication fork speed underlies cell fate changes and promotes reprogramming”) in Nature ...