For example, UV light creates cyclobutane dimers (between two thymidine residues in DNA) that stall the progression of the replication machinery. Drugs or toxins are also major causes of DNA damage.

For example, regions of the genome that are rich in guanine bases (represented by G in the DNA code) can fold into a DNA ...

New imaging tools reveal how within an hour of infection, the virus begins to alter our chromosomes to kick-start its own replication.

And one of the things it can get stuck on is the DNA template itself, which can adopt alternative structures in certain contexts. For example, regions of the genome that are rich in guanine bases ...

However, there are other causes of replication stress. For example, there's something called oncogene-induced replication stress, which can happen when there's amplification or overexpression of ...

Error-prone DNA replication and repair may lead to mutations and cancer in individuals who inherit a mutant copy of the BRCA1 gene, according to a new study by Weill Cornell Medicine investigators.

AI-powered analysis combined with long-read sequencing unveils intricate details of DNA replication, paving the way for breakthroughs in genetic research. ... For example, in cancer—marked by rapidly ...

Glucose levels influence physiology and adaptation rates under replication stress, yet core adaptive mutations remain ...

These analogs can interfere with DNA replication and induce cell death in rapidly dividing cancer cells or inhibit viral replication. Examples include: 5-Fluorouracil (5-FU): A pyrimidine analog used ...

If someone tested a sample of the water, these pieces of DNA could indicate the recent presence of the fish, even if no fish is seen. Video with audio description (5 minutes 18 seconds). The benefits ...

Cryo-electron microscopy reveals hidden mechanics of DNA replication, sheds new light on cancer target Date: March 10, 2025 ... For example, regions of the genome that are rich in guanine bases ...