In this report, we describe the impact of our approach of using attenuated, membrane-lytic peptides for the cytosolic targeting of bioactive proteins including saporin (ribosome-inactivating ...

Hsp104, a cytosolic chaperone and disaggregator, was necessary for the translocation of FlucSM into the matrix. Li hypothesized that Hsp104 detangles protein “hairballs” on the mitochondrial surface, ...

Therefore, cells have developed another strategy to get rid of faulty mitochondrial proteins and maintain cellular homeostasis”, says Park. “We identified the cytosolic protein Vms1 as a key component ...

In cells overexpressing the deubiquitinase, the researchers noticed an abundance of GFP, which was expressed as a cytosolic protein, floating in the cell medium. “This made me wonder how a cytosolic ...

This work identifies βHB as a global regulator of cytosolic protein solubility, and identifies new metabolism-related mechanistic targets for therapeutic development in aging and AD.” ...

Bottom left shows the cytosolic viscosity of untreated ALS neurons ("CTRL") and neurons treated with NMN. The intensity of the color indicates the concentration of fluorescent molecules. Credit ...

An article in Protein & Cell discusses the multifactorial ... The paper is titled "Dietary pyruvate targets cytosolic phospholipase A2 to mitigate inflammation and obesity in mice." ...

As part of their experiments, the researchers found that boosting ATP production using NMN rescued cytosolic fluidity by breaking up and solubilizing existing protein aggregates in axons from ALS ...