Those who inherit two mutations develop cystic fibrosis. The type of mutation someone carries can influence the severity of the condition and the treatment options that may be available.

People with cystic fibrosis have a gene mutation that causes problems with ... and how medications can help counter these problems. CFTR is a type of protein called an ion channel.

Cystic fibrosis (CF) is a genetic disorder ... There are more than 1,700 known mutations of the CFTR gene. Ninety percent of those affected have at least one copy of the F508del mutation.

helping reduce the symptoms of cystic fibrosis. However, these medications are only effective in people with specific CFTR mutations. Therefore, doctors will choose the type of CTFR modulator ...

Study maps proteostasis changes in cystic fibrosis variants, revealing NBD1 structural instabilities that limit drug response ...

The Cystic Fibrosis Foundation is providing funds ... How many people have these types of mutations, and what is known about the demographics of these populations? Rowe: The work with Prime ...

More than 2,500 different types of mutations on the CFTR gene can cause cystic fibrosis, Trivedi reported. Ancestry plays a large role in which mutations develop, but in the U.S., many tests only ...

Alyftrek is a type of medicine called a CFTR modulator. Alyftrek is designed to help make the broken CFTR protein in people with cystic fibrosis work better. Since different genetic mutations can ...

Cystic fibrosis is caused by a defective protein ... now there are certainly a set of patients that don’t have those types of mutations that still have very severe CF, and we’re actually ...

The severity and type of clinical manifestations are ... efficient and sensitive assay for simultaneous analysis of multiple cystic fibrosis mutations. Hum Mutat 1993;2:185–191.