The all-too-common deadly disease of young people, cystic fibrosis (CF), is caused by failure of a chloride-ion channel with the unwieldy name of CFTR, standing for cystic fibrosis transmembrane ...

This name posed a problem for those who thought that a chloride channel was primarily responsible for the clinical manifestations of cystic fibrosis. The protein contains 1480 amino acids and a ...

Discover how cystic fibrosis genetics affect inheritance patterns and symptom. Learn about CFTR mutations, testing options, ...

The CFTR protein functions as a channel across ... mutations to this gene. Cystic fibrosis most often affects the lungs. The CFTR proteins affect how water and chloride move in and out of cells ...

This reduces the function of the chloride channel. What is the most common type of cystic fibrosis? The most common type of cystic fibrosis is delta F508, which is a class 2 protein processing ...

The work was supported by the National Science Foundation. In healthy lungs, chloride ions exit the cell via a tube-shaped protein channel called a cystic fibrosis transmembrane conductance regulator ...

A UB-led research team has developed molecules that could help unclog thick, sticky mucus from the lungs of people suffering from cystic fibrosis. The chronic disease is caused by a defective protein ...

With more than 70,000 people living with cystic fibrosis (CF) worldwide, according to the Cystic Fibrosis Foundation, the introduction of CF transmembrane conductance regulator (CFTR) modulator ...

In cystic fibrosis patients, a genetic mutation prevents the CFTR chloride channel from working properly in the mucosal cells of the airways, resulting in very viscous mucus. "Ivacaftor is a drug ...

People with cystic ... Ion channels sit in cell membranes (the outer layer of cells) and allow specific ions to enter or exit the cell. CFTR controls the passage of chloride ions in and out ...

Close to 2,000 people in West Virginia and Ohio were living with Cystic Fibrosis in 2023, according to the Cystic Fibrosis ...