Cell-cycle transitions in higher eukaryotes are regulated by different cyclin-dependent kinases (CDKs) and cyclins. Recent work using gene-targeted mice has led to a revision of this model and ...

Cyclin-dependent kinase 6 (CDK6) bound to the inhibitor ribociclib (detail view). Enzyme involved in cell cycle regulation and target of several antitumoral drugs. 3D rendering.

Phosphorylation by CDK-2-cyclin E complex prevents this inhibition and so progression from G1 to S phase can continue. Overall, cyclins are responsible for the progression of the cell cycle ...

Phosphorylation can have profound effects on protein conformation and function that regulate many cellular processes, including the complex cascade of events that control cell cycle progression ... an ...

Somatic inactivating variants in the gene CDK12, encoding cyclin-dependent kinase 12, generate fusion-induced neoantigens in prostate cancer. This finding supports the hypothesis that prostate canc ...