Cyclin specificity could therefore trigger the sequential occurrence of events to reinforce the unidirectionality of the cell cycle, both at the level of the cell-cycle engine and at the level of ...

However, the other cyclin levels rise and fall when they are required ... The function of cyclins in the cell cycle Cyclins have no enzymatic function of their own, and instead bind to CDKs ...

Cyclin dependent kinases are present at constant levels throughout the cell cycle, but are only active in the presence of cyclins. Once bound to a cyclin they act to phosphorylate many target ...

Cyclin E, a regulator of the cell cycle, affects the behavior of breast-cancer cells. We investigated whether levels of cyclin E in the tumor correlated with survival among patients with breast ...

The expression levels of two closely linked ... described fly-FUCCI in 2014 (5). To see the cell-cycle progression, they fused GFP to the degron of E2F and mRFP (red fluorescent protein) to the degron ...

which are finely regulated at the level of gene expression, protein synthesis, degradation and phosphorylation. The cyclins activate the cyclin-dependent kinases, which promote cell cycle progression.

the cyclin-dependent kinases (CDKs) -4 and -6, thus controlling the G1 phase and the G1/S-phase transition of the cell cycle. Elevated levels of Cyclin D1 expression in MCL cells may accelerate ...

Critical parts of the cell cycle machinery are the cyclin-dependent kinases (CDKs), which, when activated, provide a means for the cell to move from one phase of the cell cycle to the next. The CDKs ...

Press Release Circle Pharma, a clinical-stage biopharmaceutical company advancing macrocycle therapeutics for difficult-to-treat cancers, today announced that its Trials in Progress abstract has been ...

Cyclin B1 is relevant in mitosis, a type of cell division. The researchers observed how cyclin B1 docks onto substrates with its pocket and influences the behavior of the kinase as a result.

which are finely regulated at the level of gene expression, protein synthesis, degradation and phosphorylation. The cyclins activate the cyclin-dependent kinases, which promote cell cycle progression.