How CRISPR Works: Unpacking the Science of Cas9 and Gene Modification

Discover how CRISPR genome editing is revolutionizing medicine. Learn the science of Cas9, current clinical trials, and the future of gene editing.
The Scientist

Optimizing Gene Editing with PARP1 CRISPR Plasmids

Gene editing is revolutionizing the understanding of health and disease, providing researchers with vast opportunities to advance the development of novel treatment approaches. Traditionally, ...
GEN

Prime Editing for Isogenic iPSCs, PRINT, Universal In Vivo CAR T Editing, Biogen Q4 Results Disappoint; Andrea Choe

Episode 10 (February 23, 2024): Researchers from Francis Collins’ lab developed an efficient CRISPR prime editing protocol to generate isogenic-induced pluripotent stem cell (iPSC) lines carrying ...
The Scientist

Avoiding Gene Editing’s Unintended Consequences

To investigate how Cas9 gene editing affected T cells, the researchers targeted the first exon of the TRAC locus, which encodes the T cell receptor on chromosome 14. As expected, DNA sequencing ...
Forbes

Could CRISPR Genome Editing Technology Impact Your Business?

Forbes contributors publish independent expert analyses and insights. Peter Bendor-Samuel is founder & executive chairman of Everest Group. One of the SciTech trends I’m currently paying attention to ...
EurekAlert!

Ex vivo gene editing and cell therapy for hereditary tyrosinemia type 1

Background: We previously demonstrated the successful use of in vivo CRISPR gene editing to delete 4-hydroxyphenylpyruvate dioxygenase (HPD) to rescue mice deficient in fumarylacetoacetate hydrolase ...
New Scientist

'Bridge editing' could be even better at altering DNA than CRISPR

A powerful form of DNA-editing machinery discovered in bacteria might allow us to make much bigger changes to genomes than is currently possible with CRISPR-based techniques. However, it isn’t yet ...