The combination of BC and GP downregulates the 5-LOX inflammatory pathway by inhibiting activation of MG and promotes M1-to-M2 polarization of MG. Neurons are protected by the M2-type polarization ...

Overexpression of COX-2 or 5-LOX increases levels of PGE-2 and 5-HETE, respectively. Elevated levels of VEGF are common in patients with non- small cell lung cancer (NSCLC). We prospectively measured ...

The most dominant polyunsaturated fatty acid in mammal is oxygenated by Cyclooxygenase (COX) and Lipoxygenase (LOX) pathways which leads to the formation of compounds ‘eicosanoids’, a type of ...

Dr. Raffaella Canali of the National Research Institute on Food and Nutrition in Rome, Italy, found that Pycnogenol(R) inhibits the generation of COX-2 and 5-LOX, two naturally occurring enzymes ...