Analysis of the distribution of these isoforms suggested that COX-1 is mainly responsible for the production of homeostatic prostaglandins, whereas COX-2 is localized mainly in inflammatory cells ...

NSAIDs variably inhibit prostaglandin H synthase (COX). COX-2 was cloned in 1991, and it was subsequently established that COX-1 does not appear to play a major role in inflammation while COX-2 ...

COX-2 is involved in prostaglandin synthesis and expressed throughout the nervous system, where it participates in pain sensitivity and in synaptic plasticity. Microsomal prostaglandin E synthase ...

Medically reviewed by David Ozeri, MD Prescription anti-inflammatory medications are used to reduce pain, inflammation, and ...

mainly COX-2, and antioxidant properties. In summary, we conclude that resveratrol reduced the prostaglandin formation in neuronal cells probably by inhibiting the activity of inducible PG ...