NSAIDs work on a chemical level. They block the effects of special enzymes -- specifically Cox-1 and Cox-2 enzymes. These enzymes play a key role in making prostaglandins. By blocking the Cox ...

A novel PET imaging approach can effectively quantify a key enzyme associated with brain inflammation, according to research ...

A novel PET imaging method, using the radiotracer 11C-MC1, successfully quantifies COX-2 enzyme levels in the human brain. This technique opens the door for earlier detection, monitoring of disease ...

IC 50 values provide no indication of the mechanism of enzyme inhibition ... (defining both K i values and rate constants) of COX-1 and COX-2 need to be conducted as a first step prior to ...

COX-2 is involved in prostaglandin synthesis and expressed ... may be another important player in neural aspects of the inflammatory response. Figure 1: Regulatory checkpoints of peripheral ...

All NSAIDs variably inhibit COX-1 and COX-2 and the mechanisms of inhibition ... NSAID inhibition of COX in vitroare the source of the enzyme, the Michaelis constant (K m)of the endogenous ...

The first-in-human study, which imaged the COX-2 enzyme, offers a never-before-seen view of inflammation in the brain, ...