We present a yeast chemical-genomics approach designed to identify genes that when mutated confer drug resistance, thereby providing insight about the modes of action of compounds. We developed a ...
Vitamin B 12 (cobalamin) is an essential cofactor in several metabolic pathways. Intracellular conversion of cobalamin to its two coenzymes, adenosylcobalamin in mitochondria and methylcobalamin in ...
Genomic sequence analysis is revealing the presence of duplicated genes in all sequenced organisms. Gene duplicates can arise through tandem, segmental or global duplication events. In instances in ...
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