To gain insight into the ubiquitination reaction catalyzed by HECT E3 ligases, we set out to determine the crystal structure of the Ub-loaded HECT domain of Nedd4 in complex with Ub noncovalently ...

Once human proteins are synthesized, they undergo some chemical ... and structure. The Bhogaraju Group at EMBL Grenoble has ...

the solved structure lacked the ubiquitinated nucleosome substrate. This deficiency has severely limited the understanding of the molecular mechanism by which PR-DUB specifically removes ...

Human proteins undergo a variety of chemical modifications following their synthesis. These modifications regulate their structure, function, and stability. Researchers from the Bhogaraju Group at ...

Human proteins undergo a variety of chemical modifications following their synthesis. These modifications regulate their structure, function, and stability. Researchers from the Bhogaraju Group at ...

This study is led by Dr. Na Yang (State Key Laboratory of Medicinal Chemical Biology ... cofactor UHRF1 activates DNMT1 in a histone H3 ubiquitination-dependent manner (Bostick et al., ...