The researchers therefore modified the chemical structure of thanatin to enhance the peptide's characteristics. "To do this, structural analyses were essential," says Zerbe.

The therapeutic use of antibiotics has been severely ... bonding distance to N6 of A2045Dr (A2062Ec). Our structure explains why the chemical footprinting experiments implicate this nucleotide ...

The work, he says, “underscores the pivotal role that chemical synthesis plays in the design and development of potentially useful and novel antibiotics.” Seiple says the group will keep ...

Figure 1: Cryo-EM structure of the ErmBL-stalled ribosome ... the cooperative action of nascent peptides and tunnel-binding antibiotics. Ribosomal particles were diluted in buffer A to a final ...

They published MurJ's molecular structure on Dec. 26 in Nature Structural ... understanding of cell wall construction to develop new antibiotics in the face of mounting antibacterial resistance.