The standard eukaryotic cell cycle consists of four phases: G1, S, G2, and M phases. There are three phase transitions in a cell cycle: G1/S to initiate DNA synthesis, G2/M to enter mitosis ...

In an emerging model of quiescence, whether CDC6 is loaded on the chromatin or not might represent an important distinction between cells that will continue through G1 to S phase versus those that ...

This sequential expression followed the phases of the traditional cell cycle: G0/G1 (the cell grows larger), S (the cell replicates its DNA), and G2/M (the cell prepares for division and then splits).

leading to cell cycle arrest in the G1 phase. Further investigation into the role of CDK4/CDK6 in ESCC was conducted through CRISPR-mediated gene knockout experiments. The depletion of CDK4/CDK6 ...

PHEC-66's impact extends to the modulation of cell cycle progression, particularly evident in the sub G1 and sub G1/G1 phases ...

This study presents fundamental insights into overcoming resistance in hormone receptor-positive breast cancer by demonstrating that sustained CDK4/6 inhibitor treatment, either alone or in ...