May be antagonized by phenobarbital, phenytoin, others (may need to increase caffeine dose). Caution with CYP1A2 substrates, inhibitors, or inducers.

PAHs are potent inducers of the hepatic cytochrome P-450 ... an important consideration is how quickly the induction of CYP1A2 dissipates. The primary pharmacokinetic interactions with smoking ...