Oxygenases have long been thought to require a cofactor for catalysis. The structure of a vancomycin biosynthetic enzyme in complex with a substrate analog, and with molecular oxygen bound in its ...

The researchers used site-specific mutagenesis to gain new insights into how the cofactor precursor is integrated into the enzyme and how individual amino acids are involved in anchoring and ...

These cofactors, or coenzymes, provide additional functionality that extends considerably the scope of enzyme-catalyzed reactions. Some cofactors (including the iron-porphyrin prosthetic groups of ...

The Stull lab primarily focuses on the class of enzymes that use riboflavin-derived cofactors (flavin-dependent enzymes), which catalyze a wide array of chemical transformations that are crucial for ...