COX-2 was cloned in 1991 ... COX is a heme-containing bifunctional protein that sequentially catalyzes two reactions, a COX and a peroxidase reaction. The presence of an endogenous oxidant ...

COX-2 levels increase during developmental synaptic remodeling 5 and upregulation of synaptic activity 6. Moreover, COX-2 is involved in the coupling of synaptic plasticity with cerebral blood flow 7.

Meloxicam is an enolcarboxamide with preferential COX-2 activity. Studies conducted on experimental models and human tissues indicate that meloxicam is a more potent inhibitor of COX-2 than COX-1 ...