This simplistic division of the roles of COX-1 and COX-2 drove the search for 'selective' COX-2 inhibitors and further fuelled the ranking of NSAIDs in terms of their relative selectivity for COX ...

Aspirin And Other Non-Specific Cox Inhibitors May Slow Atherosclerosis Date: March 14, 2001 Source: University Of Pennsylvania Medical Center Summary: ...

New research reveals why COX-2 inhibitors such as Vioxx can cause heart attacks and strokes. Researchers believe that their findings, published in the December issue of the Federation of American ...

COX – 2 Inhibitors act by inhibiting Cyclooxygenase–2 enzyme activity and hence inflammmation. There are two types of Cyclooxygenase (COX) enzymes, namely COX—1 and COX—2.

The COX-2 enzyme is predominantly located in the central nervous system and thus there are fewer gastrointestinal side-effects with these drugs compared to COX-1 inhibitors. Enlarge ...

Study authors from Vanderbilt University Medical Center report that prostaglandin production by macrophages may play a role in cardiovascular adverse events associated with COX-2 inhibitors.

Taken as a whole, new findings suggest that COX-2 inhibitors may be beneficial for the prevention of renal damage in obesity-related Type II diabetes.

By selectively blocking only COX-2 enzymes but not COX-1, COX-2 inhibitors ease inflammation and pain with fewer adverse effects on your gastrointestinal tract than other NSAIDs. [2] ...

AAT-076 was tested in the preclinical setting for its analgesic potential in COX-1 and COX-2 assays, as well as in in vivo rat models of air pouch inflammation, adjuvant-induced arthritis and ...

It might seem simple to ditch COX-1 inhibitors such as ibuprofen or naproxen for a COX-2 inhibitor, but COX-2 inhibitors have risks of their own. A 2011 study in The BMJ compared the safety of ...

Overwhelmingly, the selectivity of NSAIDs is based on an IC 50 value (the concentration at which an NSAID produces 50% inhibition of COX-1 and/or COX-2).