Medscape1mon
Defining the COX Inhibitor Selectivity of NSAIDs: Implications for Understanding Toxicity
All NSAIDs variably inhibit COX-1 and COX-2 and the mechanisms of inhibition fall into three broad categories, although there are exceptions. For example, nimesulide is a weak competitive ...
Clinical trial finds no benefit from aspirin in preventing colorectal cancer recurrence
A new international clinical trial led by the National Cancer Center Singapore is reporting that three years of aspirin following standard adjuvant therapy for high-risk Dukes' B and C colorectal ...
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The Ibuprofen Alternative That's Better For Your Stomach (But You Need A Prescription For It)
That's because most NSAIDs, like ibuprofen, are COX-1 inhibitors, which block prostaglandins that produce inflammation. However, prostaglandins also protect your stomach lining (per the National ...
Medscape4y
Defining the COX Inhibitor Selectivity of NSAIDs: Implications for Understanding Toxicity
Selectivity of NSAIDs is currently based on an IC 50 value (the concentration at which an NSAID produces 50% inhibition of COX-1 and/ or COX-2). IC 50 values provide no indication of the ...