in addition to maintenance of wild-type Sprague Dawley strain for additional use Generation and procurement of novel relevant CF animal models to understand newly developed CFTR modulators, and to ...

The researchers looked at medical records of women who were either on or off modulators who became pregnant in the last 10 ...

Join Peter Grootenhuis of Vertex Pharmaceuticals as he delivers a brief overview of the drug discovery approaches and challenges to identify small molecules CFTR modulators. These compounds improve ...

Vertex's products are known as cystic fibrosis transmembrane conductance regulator modulators, or CFTR modulators, and they "fix" the malfunctioning protein made by the CFTR gene. Now the tricky ...

With BI 3720931, Boehringer and its partners are hoping to fulfil that need and provide an option for the estimated 10% to 15% of patients for whom there are no suitable CFTR modulators available.

and the evaluation and rapidly evolving role of CFTR modulators in human subjects, including a variety of effects on the endocrine and digestive system. The Clinical and Translational Core, ...

People with cystic fibrosis have better treatment options available today than ever before, with the advent of ‘CFTR modulator’ drugs. However, there are still many patients who are unable to ...

DENVER - A recent retrospective study published in CHEST(Opens in a new window) evaluated the effects of cystic fibrosis transmembrane conductance regulator (CFTR) modulator use on pregnancy ...

Get Instant Summarized Text (Gist) A study across 11 U.S. CF centers analyzed 307 pregnancies from 2010 to 2021, assessing the impact of CFTR modulators on pregnancy outcomes in individuals with ...