Most efforts to understand this process have thus focused on mechanisms that govern the hepatic secretion of biliary cholesterol, phospholipids, and bile salts. Currently, hepatic secretion of ...

Biliary cholesterol secretion may also be manipulated by influencing cholesterol synthesis, transport, or nuclear regulation. Although inhibition of HMG-CoA reductase has not proven very useful ...

a day to effect the secretion of about 2 g of cholesterol. The hepatocyte forms a boundary between "inside" (the blood) and "outside" (the biliary tree, leading to the intestinal lumen).

because the intestinal cholesterol pool is expanded by effective biliary cholesterol secretion. We thank the Finnish Diabetes Research Foundation, Helsinki University Central Hospital, and the ...

This system is needed for the production, storage, and secretion of bile ... of material that can form in your gallbladder. They can be made up of cholesterol or a bile salt called bilirubin ...

The loss of bile ducts leads to decreased bile secretion ... persons with primary biliary cirrhosis do not seem to be at increased risk for death from atherosclerosis. 63 Cholesterol-lowering ...

Alongside genetic predisposition, various pathogenic factors contribute to GSD, such as heightened biliary mucin secretion, excessive hepatic cholesterol secretion, formation of supersaturated ...

The process of reverse cholesterol transport (RCT) has long been thought require intact biliary secretion. However, our work has revealed a novel RCT pathway that is independent of biliary secretion.

1,2 We previously showed that patients with primary biliary cirrhosis and extreme hypercholesterolemia (total cholesterol level, >25.86 mmol per liter) had a substantial proportion of circulating ...