Chronic lymphocytic leukemia (CLL) is a B-cell malignancy, with disease progression ranging from slow and indolent to ...

Immune dysregulation is often defined as an immune response that is directed against one of the body’s own tissues, cells or molecules (e.g. autoimmunity) or against an innocuous foreign molecule that ...

Science is full of ideas that have been proven wrong. Up until the 1950s, one prevailing view among scientists was that the body could not produce antibodies against itself. This concept, known as ...

Aly et al. [17] provided evidence that risk for islet autoimmunity drastically increased in DR3/4-DQ2/DQ8 siblings who shared both HLA haplotypes identical by descent with their diabetic proband ...

For the past 40 or 50 years, researchers searched for the trigger behind sex-biased autoimmunity. “We have thought that the X chromosome had something to do with the autoimmune predominance. This ...

Studies performed during the past 2 years have provided a deeper understanding into the role of CTLA-4, which is expressed on regulatory T cells, in preventing autoimmunity, and also provide ...

Please provide your email address to receive an email when new articles are posted on . On this episode, hear the 2024 updates on COVID-19, long COVID and the latest developments in research in ...

Building on its traditional strengths in immunology and autoimmunity, the Center faculty has developed programs in translational human genetics, focusing on the immunogenetic basis of autoimmune ...

Advances in our understanding of autoimmunity and tumour immunity have led to improvements in immunotherapy for these diseases. Ironically, effective tumour immunity requires the induction of the ...

reducing Treg cells that are crucial for maintaining immune tolerance and for the control of inflammation and autoimmunity. Most autoimmune and inflammatory diseases exhibit disturbances in Treg ...

Discover a study that explores the effectiveness of JAK inhibitors to treat dermatological autoimmunity for people with Down ...

A balance between immunity and tolerance is required as any disturbance may result in chronic inflammation or autoimmunity. Dendritic cells (DCs) actively participate in maintaining this balance.