Prostaglandins, thromboxanes and prostacyclins ... The key precursor fatty acid is arachidonic acid, which is an essential fatty acid as it cannot be synthesized de novo in animals.

First, the prostaglandins were extremely potent ... the major branching pathways that lead from arachidonic acid to the eicosanoids are shown in Figure 5. Note that the COX enzymes are positioned ...

Aspirin-induced bronchoconstriction is thought to be caused by the shunting of the arachidonic acid metabolism away ... In addition, the removal of the prostaglandin (PG) E2 brake in all subjects ...

It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins ... of their common precursor, arachidonic acid. Treat infection if present ...

Mucosal production of arachidonic acid metabolites ... diminishes inflammation by blocking cyclooxygenase and inhibiting prostaglandin production in the colon. Increased toxicity with nephrotoxic ...