This mechanism is antigen-nonspecific, is mediated by arachidonic acid metabolites produced by a cyclooxygenase-2 (COX-2)-dependent pathway and can be overcome by inhibition of COX function with ...

The arachidonic acid (AA) metabolism pathway ... was significantly better in patients with low levels of 5-LOX or COX-2 expression than those with high levels 25. Lipid autacoids that are CYP ...

By inhibiting the COX pathway, aspirin diverts arachidonic acid metabolites to the LO pathway. This also leads to a decrease in the levels of prostaglandin (PG) E2, the anti-inflammatory PG ...

Also, they compete for cyclooxygenase and ... cell membranes and subsequent metabolism, high intake of the omega-6 fatty acids will result in an increased production of unhealthy eicosanoids derived ...

"This indicated that Celebrex 'shunted' or redirected arachidonic acid into the 5-LO pathway from the COX pathway. When one went down, the other went up." This is important because other studies ...

Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID). Other examples of drugs in this class include aspirin and diclofenac. Taken together, these drugs are all pain relievers that are used ...

Notably, by tampering with the arachidonic acid pathway in mice bred to develop the biological hallmarks of ALS, the researchers say they were able to reduce the condition's muscle-weakening ...

Leukotrienes are inflammatory mediators generated from arachidonic acid ... by the 5-lipoxygenase pathway. Increased dietary intake of n–6 fatty acids (arachidonic acid and its metabolic ...

HAN Wei from Hefei Institutes of Physical Science (HFIPS), Chinese Academy of Sciences (CAS) found, for the first time, that dietary arachidonic acid (AA ... AMPK signaling pathway was activated ...

In reality, however, the impact of arachidonic acid, an omega-6 polyunsaturated ... and host to understand how the microbiome affects metabolism and physiology," Cross said.

K. Suresh Babu, MD, DNB; and Sundeep S. Salvi, MD, DNB, PhD, From the Department of Respiratory Cell and Molecular Biology, University of Southampton, Southampton ...