Typical antipsychotic drugs act on the dopaminergic system, blocking the dopamine type 2 (D2) receptors. Atypical antipsychotics have lower affinity ... Milwaukee), at the Maudsley Hospital ...

In preliminary studies, we discovered that selected typical and atypical antipsychotic drugs interacted with virtually every biogenic amine receptor tested, in confirmation of many prior studies ...

Antipsychotics with a high binding affinity for alpha-2-adrenergic and M1-muscarinic receptors are associated with a greater risk for stroke than other types of antipsychotics, new research suggests.

and low affinity for 5-HT 1A, D 1, and histamine H1 receptors. It acts as an antagonist at norepinephrine 1 / 2C receptors as well. Along with its antipsychotic effects, it can cause ...

In the journal Neuron, the researchers report that antipsychotics side-effects are due to blockade of the dopamine D2 receptor in a specialized type of neurons in the striatum, called interneurons.