Thirty years after the description of a direct linear correlation between dopamine (DA) D 2 receptor-binding affinities and antipsychotic drug potencies for ameliorating psychosis (Seeman et al ...

Comparison of Weight Gain with Selected Biogenic Amine Receptor Affinities Since reliable weight gain data are available for only a subset of antipsychotic drugs (Allison et al, 1999), we more ...

such as the 5-HT 1A receptor, are considered to mediate the ability of antipsychotic drugs to enhance cognition. On the other hand, treatment with some atypical agents, such as risperidone ...

Molecular secrets revealed: Antipsychotic docked in its receptor. ScienceDaily . Retrieved June 2, 2025 from www.sciencedaily.com / releases / 2018 / 01 / 180131090320.htm ...

Roth of the University of North Carolina, Chapel Hill, announced that he and his colleagues were trying to solve the structure of the D 2 dopamine receptor (DRD2), a target of many antipsychotic ...

Now, scientists at the UNC School of Medicine and UC San Francisco (UCSF) have solved the first high-resolution crystal structure of the dopamine 2 receptor (DRD2) bound to the antipsychotic drug ...

‘Weight-loss drug that targets the serotonin 2c receptor may eliminate most of the metabolic changes caused by antipsychotic drugs.’ "Atypical antipsychotics are essential medications for ...

Dopamine is a key for both receptors, but antipsychotics only block the D2 receptor locks. Therefore, experts have assumed these drugs preferentially act on neurons that express the D2 receptor locks.

New University of Pittsburgh research points to a potential approach to reducing the risk of diabetes associated with widely-prescribed antipsychotic medications. The study presents early evidence ...

The work showed, however, that all nine antipsychotic drugs examined uniformly and more potently block the beta-arrestin pathway downstream of the D2 dopamine receptor. Since G-protein coupled ...

Many of these side effects result from existing antipsychotics’ interaction with several other types of receptors, in addition to the D2 receptor. Consequently, an in-depth understanding of the ...

Credit: Thinkstock. Antipsychotics used to treat disorders such as schizophrenia, bipolar disorder, and other psychoses mainly involve D2 receptor antagonism and some newer agents target D4 ...