The immune system produces a huge variety – hundreds of billions – of high-affinity antibodies. Immunologists have been asking how B cells accomplish this for decades, and in the past five years, the ...

ADLib creates diversified libraries of antibodies using DT40 cells, a line of avian B cells. The ADLib system generates diversity in the immunoglobulin gene through gene conversion, enhanced by ...

with a coverage of up to 10 1 native antibody fragments (next-generation-sequencing-verified diversity). By performing the whole antibody-discovery process in vitro and bypassing animal ...

An antibody discovery platform revealed more than 60 monoclonal antibodies specific to patients with alpha-gal syndrome, according to a poster presented here. This molecular characterization may ...

Existing monoclonal antibody development technologies, such as hybridoma technology, suffer from a loss of diversity due to cell fusion efficiency, and phage display technology creates antibodies ...

The first is to conduct antibody tests to gauge the level of immunity developed against COVID-19 among devotees. The second is to analyse the diversity of DNA present in the crowd, given that ...

"A few previously reported cases of de novo antibody design have shown only limited success, particularly in terms of target diversity and binding affinity. Our findings prove that AI can reliably ...

De novo antibody design has been one of the major challenges in AI-based drug discovery, requiring atomic-level precision to ...