Preladenant is a selective antagonist of the adenosine 2A receptor; animal data suggest that agents that target this receptor may improve motor function in PD without inducing dyskinesias ...

Adenosine receptors (ARs) are a group of G protein-coupled receptors that play a significant role in various physiological processes, including immune modulation. Recent research has increasingly ...

Exploration of adenosine mechanism revealed adenosine receptors as a potentially useful target of therapy in RA.

More than two years after acquiring Tarus Therapeutics, Portage Biotech is relaunching Tarus’ adenosine receptor antagonists in a standalone company helmed by a familiar leader. The offshoot ...

To determine if this is caused by the cerebral vasodilator adenosine (ADO), we studied the effects of 8-sulphophenyl-theophylline (8-SPT), an ADO receptor antagonist on HG-induced dilation of PA.

Dopamine’s effects in the brain are mediated by postsynaptic D1 and D2 receptors. Adenosine A1 and A2A receptors are uniquely positioned to counteract the excessive stimulation of dopamine receptors ...

The half-life is 6 seconds. Adenosine receptor activation results in multiple different actions depending on the location. Adenosine plays an important role in energy transfer (adenosine ...

The potential mechanisms of caffeine’s action include its role as an adenosine receptor antagonist that reverses the tonic inhibitory influence of adenosine in the central nervous system. By ...