Mechanisms of resistance to castration have historically been thought to be androgen independent. This misconception was dismissed and it is now apparent that signaling through the AR continues to ...

The researchers further confirmed the androgen receptor-fucosyltransferase-4 axis modulation of cell signaling pathways in melanoma by creating empty vector (EV) controls or fucosyltransferase 4 ...

Although it is well established that the androgen receptor is important for prostate ... We found that when androgens activated this signaling pathway, it hijacked normal conditions, allowing ...

It was a surprising result to show that these cells could continue to live without the androgen receptor signaling. Combining drugs that hit both pathways will be much more effective than using ...

Patients with metastatic castration-sensitive prostate cancer (mCSPC), who have specific genetic mutations, were found to ...

The first finding showed that TBX2 drives therapy resistance in castrate-resistant prostate cancer by acting as a switch, shifting the signaling pathway from the androgen receptor to the ...

The key to this resistance may lie in expression of the androgen receptor itself. Most patients with metastatic prostate cancer receive drugs that block production of androgen, which promotes ...

The first finding showed that TBX2 drives therapy resistance in castrate-resistant prostate cancer by acting as a switch, shifting the signaling pathway from the androgen receptor to the ...

Significance of Androgen Signaling Pathway for Prostate Cancer and other ... The inhibition of androgen / androgen receptor signaling can be used for the treatment and preventiojn of diseases ...