A drug that can be taken orally could soon rival the likes of Ozempic for treating type 2 diabetes and obesity, according to ...

New approach: Adrenaline receptors instead of opioid receptors. Peter Gmeiner is currently following a lead that seems very promising: “Many non-opioid receptors are involved in pain processing, but ...

Beta-adrenergic signaling mechanisms are of central importance to cardiovascular health and disease. Modulation of these pathways represents an important pharmacologic approach to the treatment of ...

While many non-opioid receptors are involved in pain processing, very few have been validated for therapeutic use. As such, in the present study, researchers focused on the alpha 2A adrenergic ...

PAG was shown to interact with beta-2 adrenergic receptors to influence how forcefully the heart muscle cells contract—a process that investigators believe contributes to heart failure.

Notably, the α 2a-adrenergic receptor is expressed in brain regions involved in pain modulation, and α 2a-adrenergic agonists (i.e., drugs that activate this receptor can alleviate chronic and ...

The addition of β-adrenergic receptor antagonists to a medical regimen for heart failure that includes angiotensin-converting enzyme (ACE) inhibitors as background therapy has been associated ...

Dr. Hazen says these results indicate that beta-2 adrenergic receptors can be regulated from a second PAG binding site that acts as a custom "dimmer switch” for the adrenaline signaling pathway.

Epinephrine and norepinephrine sound alike, and they also share many of the same functions. ... Beta receptors are in the heart, lungs, and arteries of skeletal muscles.

New substances that activate adrenalin receptors instead of opioid receptors have a similar pain relieving effect to opiates, but without the negative aspects such as respiratory depression and ...