The signal transduction cascade begins when adenylyl cyclase, a membrane- bound enzyme, becomes activated by G-protein molecules associated with the adrenergic receptor. Adenylyl cyclase creates ...

The promising compound was an inhibitor for soluble adenylyl cyclase (sAC), an enzyme that exists in almost every cell across the body, but is particularly essential to the flagellum that a sperm cell ...

You have full access to this article via your institution. The authors suggest that glutaminyl cyclase inhibition could provide a new therapeutic option in patients with AD or other amyloidoses.

The goal of this research is to determine whether inhibition of specific PDEs from these organisms ... A fission yeast platform for heterologous expression of mammalian adenylyl cyclases and high ...