It is well known that the intracellular level of the second messenger cyclic adenosine monophosphate (cAMP) is controlled by the adenylate cyclase ... of cAMP-PKA pathway with nuclear receptor ...

A balance between the activity of enzymes, including cyclic nucleotide phosphodiesterase (PDE) and adenylyl cyclase ... cAMP. The process of the cAMP signaling pathway depends upon PKA.

In that case, BACE1 may not necessarily cleave adenylate cyclase, but another substrate that acts on the cAMP/PKA/CREB pathway, he told Alzforum. However, it is also conceivable that BACE1 has a ...

GPCRs that couple with adenylate cyclase will increase or decrease intracellular cAMP levels. The assay is based on the principle that cAMP stimulates protein kinase A (PKA) holoenzyme activity ...

"We have shown that it is through an elevation in intracellular AMP [adenosine monophosphate] that metformin substantially abrogates the activation of adenylate cyclase ... cAMP were reduced, as ...

This lead to the dissociation of the regulatory and catalytic subunits of protein kinase A (PKA), rendering ... inhibitor rolipram or the adenylate cyclase activator forskolin, both of which would ...