To clarify the mechanism by which morphine affects sleep–wake behavior, we investigated the effects of morphine on the sleep-promoting neurons of the ventrolateral preoptic area (VLPO), a ...

A new paper finds that rapid eye movement (REM) sleep is suppressed by adenosine acting on a specific subtype of adenosine receptors, the A2A receptors, in the olfactory bulb. The regulation and ...

Adenosine A 2A receptors (A 2A R) in the nucleus accumbens of the brain play an important role in regulating sleep and motivation, but until now, no drugs have been able to selectively modulate ...

Panel C shows the EEG patterns during the stages of sleep ... α 2 receptors on neurons from the locus ceruleus, inhibiting norepinephrine release (dashed line) in the ventrolateral preoptic ...

The ventrolateral preoptic nucleus ... in the preoptic area including the VLPO. The work provides important information to understand the mechanisms that control animals' sleep/wakefulness ...

As more adenosine builds up, more receptors are triggered, and the urge to sleep gets stronger. In the new study, published online January 15 in the journal Translational Psychiatry, the ...

It may also change how your brain functions during sleep, especially in 20-somethings ... This difference may be due to changes in adenosine receptors in the brain. Adenosine is a chemical ...

More information: Yi-Qun Wang et al. Adenosine A2A receptors in the olfactory bulb suppress rapid eye movement sleep in rodents, Brain Structure and Function (2016). DOI: 10.1007/s00429-016-1281-2 ...