NSAIDs variably inhibit prostaglandin H synthase (COX). COX-2 was cloned in 1991, and it was subsequently established that COX-1 does not appear to play a major role in inflammation while COX-2 ...

The pharmacodynamic properties of meloxicam have been reviewed by various authors, including Noble & Balfour. [16] In this article, we focus on the main studies that have evaluated the affinity of ...

which appears to be the target of acetaminophen. This explains why the drug is a good painkiller, even though it has very little effect on COX-1 or COX-2. The study may help scientists discover ...

COX-1 is widely expressed and generates predominantly prostaglandins to subserve housekeeping functions, such as gastroprotection and haemostatic integrity. COX-2 is readily induced by cytokines ...

The COX-2 enzyme is predominantly located in the central nervous system and thus there are fewer gastrointestinal side-effects with these drugs compared to COX-1 inhibitors. COX-2 inhibitors have ...

New research reveals why COX-2 inhibitors such as Vioxx can cause heart attacks and strokes. Researchers believe that their findings, published in the December issue of the Federation of American ...