AVI-4303, which is a C5 benzotriazole analog, exhibited ten-fold higher potency than AVI-3318. Comparatively, N1 propargyl ...

A team at UC San Francisco and Gladstone Institutes has developed new drug candidates that show great promise against the ...

How does the drug work? The active drug is nirmatrelvir, a protease inhibitor, which helps keep the SARS-CoV-2 protein from replicating. SARS-CoV-2-3CL protease is an enzyme COVID-19 needs to ...

Building on her expertise in immunomics and vaccine engineering, Kaliamurthi focuses on identifying epitope segments from a highly immunogenic SARS-CoV-2 protein with potential ... The structure of ...

The group focused on the major protease (MPro), a type of enzyme, that breaks proteins into smaller pieces like a pair of molecular scissors. SARS-CoV-2 uses MPro to trim viral proteins into usable ...